SAP130 Antibody - #DF2567
| 製品: | SAP130 Antibody |
| カタログ: | DF2567 |
| タンパク質の説明: | Rabbit polyclonal antibody to SAP130 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 135 kDa; 110kD(Calculated). |
| ユニプロット: | Q9H0E3 |
| RRID: | AB_2839773 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2567, RRID:AB_2839773.
折りたたみ／展開
130 kDa Sin3-associated polypeptide; FLJ12761; Histone deacetylase complex subunit SAP130; KIAA0017; mSin3A associated protein 130; Pre mRNA splicing factor SF3b 130 kDa subunit; RSE1; SAP 130; Sap130; SF3b 130; SF3b130; SF3B3; Sin3-associated polypeptide p130; Sin3A associated protein 130kDa; Sin3A associated protein; SP130_HUMAN; Spliceosome associated protein 130; Splicing factor 3b subunit 3 130kDa; Splicing factor 3b subunit 3; STAF 130; STAF130;
免疫原
- Q9H0E3 SP130_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV
PTMs - Q9H0E3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R5 | Methylation | Uniprot | |
| R34 | Methylation | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| R232 | Methylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| R344 | Methylation | Uniprot | |
| S349 | Phosphorylation | Uniprot | |
| T355 | Phosphorylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| R444 | Methylation | Uniprot | |
| R453 | Methylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| R463 | Methylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| T677 | Phosphorylation | Uniprot | |
| K783 | Sumoylation | Uniprot | |
| K785 | Sumoylation | Uniprot | |
| S831 | Phosphorylation | Uniprot | |
| T853 | Phosphorylation | Uniprot | |
| S855 | Phosphorylation | Uniprot | |
| T856 | Phosphorylation | Uniprot | |
| K869 | Methylation | Uniprot | |
| K869 | Sumoylation | Uniprot | |
| S875 | Phosphorylation | Uniprot | |
| Y880 | Phosphorylation | Uniprot | |
| K937 | Ubiquitination | Uniprot | |
| K979 | Ubiquitination | Uniprot | |
| K981 | Ubiquitination | Uniprot | |
| K1023 | Ubiquitination | Uniprot | |
| K1028 | Ubiquitination | Uniprot |
研究背景
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Acetylated.
Sumoylated with SUMO1.
Nucleus.
Expressed in various cancer cell ines.
Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts (released by dead or dying cells) with CLEC4E (By similarity).
The N-terminus may interact with a transcriptional coactivator.
The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.
Belongs to the SAP130 family.
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