ANAPC4 Antibody - #DF2570
| 製品: | ANAPC4 Antibody |
| カタログ: | DF2570 |
| タンパク質の説明: | Rabbit polyclonal antibody to ANAPC4 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 92 kDa; 92kD(Calculated). |
| ユニプロット: | Q9UJX5 |
| RRID: | AB_2839776 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2570, RRID:AB_2839776.
折りたたみ／展開
ANAPC 4; anapc4; Anaphase Promoting Complex Subunit 4; Anaphase-promoting complex subunit 4; APC 4; APC Complex Protein CUT20; APC4; APC4_HUMAN; CUT20; Cyclosome subunit 4; LID1;
免疫原
- Q9UJX5 APC4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKPADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQYVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESEAENQQAGAAALAPEIVIKVEKLDPELDS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UJX5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R3 | Methylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| T429 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| T446 | Phosphorylation | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| Y469 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| K508 | Ubiquitination | Uniprot | |
| Y516 | Phosphorylation | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| K526 | Ubiquitination | Uniprot | |
| Y625 | Phosphorylation | Uniprot | |
| T627 | Phosphorylation | Uniprot | |
| T628 | Phosphorylation | Uniprot | |
| K630 | Acetylation | Uniprot | |
| S736 | Phosphorylation | Uniprot | |
| S757 | Phosphorylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| K772 | Sumoylation | Uniprot | |
| S777 | Phosphorylation | Uniprot | |
| S779 | Phosphorylation | P06493 (CDK1) , P53350 (PLK1) | Uniprot |
| K798 | Sumoylation | Uniprot |
研究背景
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. In the context of the APC/C complex, directly interacts with UBE2S.
Belongs to the APC4 family.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis. (View pathway)
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
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