ZBTB16 Antibody - #DF2611
(2)
(2)
| 製品: | ZBTB16 Antibody |
| カタログ: | DF2611 |
| タンパク質の説明: | Rabbit polyclonal antibody to ZBTB16 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Rabbit, Dog, Chicken |
| 分子量: | 85 kDa; 74kD(Calculated). |
| ユニプロット: | Q05516 |
| RRID: | AB_2839817 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2611, RRID:AB_2839817.
折りたたみ／展開
AI467657; lu; PLZF; Promyelocytic leukemia zinc finger protein; ZBT16_HUMAN; ZBTB16; Zfp145; Zinc finger and BTB domain containing 16; zinc finger and BTB domain containing protein 16; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145 (Kruppel like expressed in promyelocytic leukemia); Zinc finger protein 145; Zinc finger protein PLZF; Znf145;
免疫原
Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
- Q05516 ZBT16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q05516 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K154 | Ubiquitination | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K242 | Sumoylation | Uniprot | |
| T282 | Phosphorylation | P24941 (CDK2) | Uniprot |
| Y334 | Phosphorylation | Uniprot | |
| K387 | Methylation | Uniprot | |
| K387 | Sumoylation | Uniprot | |
| K396 | Methylation | Uniprot | |
| K396 | Sumoylation | Uniprot | |
| T569 | Phosphorylation | Uniprot | |
| T597 | Phosphorylation | Uniprot | |
| Y630 | Phosphorylation | Uniprot | |
| K647 | Acetylation | Uniprot | |
| K650 | Acetylation | Uniprot | |
| K653 | Acetylation | Uniprot |
研究背景
Acts as a transcriptional repressor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Nucleus. Nucleus>Nuclear body.
Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
Binds EPN1. Interacts with ZBTB32 and CUL3. Interacts with ATP7B. Interacts (via C2H2-type zinc finger domains 1 and 2) with RNF112.
Belongs to the krueppel C2H2-type zinc-finger protein family.
研究領域
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
参考文献
Application: WB Species: Rat Sample: testicular tissues
Application: WB Species: rat Sample: Testicular
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