PIK3C2B Antibody - #DF2624

(1)  
製品: PIK3C2B Antibody
カタログ: DF2624
タンパク質の説明: Rabbit polyclonal antibody to PIK3C2B
アプリケーション: WB IHC
反応性: Human, Mouse
予測: Pig, Horse, Sheep, Rabbit, Dog
分子量: 185 kDa; 185kD(Calculated).
ユニプロット: O00750
RRID: AB_2839830

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(82%), Horse(82%), Sheep(80%), Rabbit(91%), Dog(82%)
クローナリティ:
Polyclonal
特異性:
PIK3C2B Antibody detects endogenous levels of total PIK3C2B.
RRID:
AB_2839830
引用形式: Affinity Biosciences Cat# DF2624, RRID:AB_2839830.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C2 PI3K; phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Phosphoinositide 3 Kinase C2 beta; Phosphoinositide 3-Kinase class 2, beta; phosphoinositide-3-kinase, class 2, beta polypeptide; PI3K C2beta; PtdIns 3 kinase C2 beta; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta;

免疫原

免疫原:
Uniprot:

O00750(P3C2B_HUMAN) >>Visit HPA database.

遺伝子(ID):
PIK3C2B(5287)
発現特異性:
O00750 P3C2B_HUMAN:

Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.

タンパク質配列:
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGSRSHGTL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
91
Pig
82
Horse
82
Dog
82
Sheep
80
Bovine
73
Chicken
64
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O00750 基板として

Site PTM Type Enzyme
T4 Phosphorylation
K12 Ubiquitination
S13 Phosphorylation
K22 Ubiquitination
Y34 Phosphorylation
K44 Ubiquitination
K50 Ubiquitination
Y68 Phosphorylation
S69 Phosphorylation
K70 Ubiquitination
K79 Ubiquitination
S115 Phosphorylation
Y127 Phosphorylation
S155 Phosphorylation
T168 Phosphorylation
S177 Phosphorylation
S179 Phosphorylation
K182 Ubiquitination
K201 Ubiquitination
S225 Phosphorylation
Y228 Phosphorylation
K241 Ubiquitination
K267 Ubiquitination
Y293 Phosphorylation
S308 Phosphorylation
K452 Ubiquitination
K465 Ubiquitination
S469 Phosphorylation
K496 Ubiquitination
K571 Ubiquitination
K617 Ubiquitination
T738 Phosphorylation
K752 Ubiquitination
K801 Ubiquitination
K818 Ubiquitination
K825 Ubiquitination
K836 Ubiquitination
K1027 Ubiquitination
K1047 Ubiquitination
K1065 Ubiquitination
K1140 Ubiquitination
T1148 Phosphorylation
S1150 Phosphorylation
K1152 Ubiquitination
K1162 Ubiquitination
K1228 Ubiquitination
K1377 Ubiquitination
K1383 Ubiquitination
Y1401 Phosphorylation
K1415 Ubiquitination
K1482 Ubiquitination
T1486 Phosphorylation
K1491 Ubiquitination
K1503 Ubiquitination
K1515 Ubiquitination
Y1541 Phosphorylation
K1552 Ubiquitination
K1563 Ubiquitination

研究背景

機能:

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

細胞の位置付け:

Microsome. Cell membrane. Cytoplasm>Cytosol. Nucleus. Endoplasmic reticulum.
Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.

サブユニット構造:

Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1.

タンパク質ファミリー:

Belongs to the PI3/PI4-kinase family.

研究領域

· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.

· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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