ING5 Antibody - #DF2634

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製品: ING5 Antibody
カタログ: DF2634
タンパク質の説明: Rabbit polyclonal antibody to ING5
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Horse, Rabbit, Dog
分子量: 28 kDa; 28kD(Calculated).
ユニプロット: Q8WYH8
RRID: AB_2839840

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Horse(82%), Rabbit(92%), Dog(92%)
クローナリティ:
Polyclonal
特異性:
ING5 Antibody detects endogenous levels of total ING5.
RRID:
AB_2839840
引用形式: Affinity Biosciences Cat# DF2634, RRID:AB_2839840.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

1700001C14Rik; 1700027H23Rik; 1810018M11Rik; FLJ23842; ING 5; Ing5; ING5_HUMAN; Inhibitor of growth family member 5; Inhibitor of growth protein 5; p28 ING 5; p28 ING5; p28ING5;

免疫原

免疫原:

A synthesized peptide derived from human ING5, corresponding to a region within the internal amino acids.

Uniprot:

Q8WYH8(ING5_HUMAN) >>Visit HPA database.

遺伝子(ID):
ING5(84289)
発現特異性:
Q8WYH8 ING5_HUMAN:

Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.

タンパク質の説明:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.
タンパク質配列:
MATAMYLEHYLDSIENLPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQRVERLQKIQNAYSKCKEYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDKMEGSDFESSGGRGLKKGRGQKEKRGSRGRGRRTSEEDTPKKKKHKGGSEFTDTILSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRCVQEKRKKK

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Dog
92
Rabbit
92
Horse
82
Chicken
73
Xenopus
67
Bovine
0
Sheep
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.

タンパク質ファミリー:

The PHD-type zinc finger mediates the binding to H3K4me3.

Belongs to the ING family.

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