KAT13A/SRC1 Antibody - #DF2648
| 製品: | KAT13A/SRC1 Antibody |
| カタログ: | DF2648 |
| タンパク質の説明: | Rabbit polyclonal antibody to KAT13A/SRC1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 200 kDa; 157kD(Calculated). |
| ユニプロット: | Q15788 |
| RRID: | AB_2839854 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2648, RRID:AB_2839854.
折りたたみ／展開
bHLHe74; Class E basic helix-loop-helix protein 74; F SRC 1; Hin 2 protein; Hin2 protein; MGC129719; MGC129720; mNRC 1; NCoA 1; NCoA-1; Ncoa1; NCOA1_HUMAN; Nuclear receptor coactivator 1; Nuclear receptor coactivator protein 1; NY REN 52 antigen; Protein Hin 2; Protein Hin-2; Protein Hin2; Renal carcinoma antigen NY REN 52; Renal carcinoma antigen NY-REN-52; RIP 160; RIP160; SRC 1; SRC-1; Steroid receptor coactivator 1;
免疫原
- Q15788 NCOA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15788 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| T26 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| T209 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S423 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| S566 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| S620 | Phosphorylation | Uniprot | |
| K632 | Acetylation | Uniprot | |
| S659 | Phosphorylation | Uniprot | |
| S698 | Phosphorylation | Uniprot | |
| K732 | Sumoylation | Uniprot | |
| K774 | Sumoylation | Uniprot | |
| T789 | Phosphorylation | Uniprot | |
| S853 | Phosphorylation | Uniprot | |
| S863 | Phosphorylation | Uniprot | |
| K959 | Ubiquitination | Uniprot | |
| T979 | Phosphorylation | Uniprot | |
| S997 | Phosphorylation | Uniprot | |
| S1006 | Phosphorylation | Uniprot | |
| T1026 | Phosphorylation | Uniprot | |
| R1029 | Methylation | Uniprot | |
| S1033 | Phosphorylation | Uniprot | |
| R1041 | Methylation | Uniprot | |
| R1114 | Methylation | Uniprot | |
| R1131 | Methylation | Uniprot | |
| T1179 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
| S1185 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| S1250 | Phosphorylation | Uniprot | |
| T1271 | Phosphorylation | Uniprot | |
| S1279 | Phosphorylation | Uniprot | |
| S1372 | Phosphorylation | Uniprot | |
| T1426 | Phosphorylation | Uniprot |
研究背景
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.
Nucleus.
Widely expressed.
Interacts with the methyltransferase CARM1 (By similarity). Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with the histone acetyltransferases EP300 and CREBBP. Interacts with PCAF, COPS5, NR3C1 and TTLL5/STAMP. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2 and DDX5. Interacts with ASXL1. Interacts with PRMT6. Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts in a ligand-dependent fashion with RXRA. Interacts with TRIP4. Interacts with NR4A3 (By similarity). Interacts with VDR.
The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity.
Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro.
Belongs to the SRC/p160 nuclear receptor coactivator family.
研究領域
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Breast cancer. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
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