POMC Antibody - #DF2655
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| 製品: | POMC Antibody |
| カタログ: | DF2655 |
| タンパク質の説明: | Rabbit polyclonal antibody to POMC |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Sheep, Dog |
| 分子量: | 29 kDa; 29kD(Calculated). |
| ユニプロット: | P01189 |
| RRID: | AB_2839861 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2655, RRID:AB_2839861.
折りたたみ／展開
ACTH; Adrenocorticotropic hormone; Adrenocorticotropin; Alpha melanocyte stimulating hormone; alpha-MSH; alphaMSH; Beta LPH; Beta melanocyte stimulating hormone; Beta-endorphin; beta-MSH; CLIP; Corticotropin; Corticotropin lipotropin; Corticotropin-like intermediary peptide; Gamma LPH; gamma-MSH; Lipotropin beta; Lipotropin gamma; Lipotropin, included; LPH; Melanocyte-stimulating hormone, included; Melanotropin alpha; Melanotropin beta; Melanotropin gamma; Melanotropin, included; Met-enkephalin; MSH; NPP; Opiomelanocortin prepropeptide; POC; POMC; Pomc-1; Pomc1; Pomc2; Pro ACTH endorphin; Pro opiomelanocortin; Pro-opiomelanocortin-alpha; Proopiomelanocortin; Proopiomelanocortin preproprotein; Tetracosactide;
免疫原
- P01189 COLI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P01189 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T71 | O-Glycosylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S230 | Phosphorylation | Uniprot |
研究背景
Stimulates the adrenal glands to release cortisol.
Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Increases the pigmentation of skin by increasing melanin production in melanocytes.
Endogenous orexigenic opiate.
Endogenous opiate.
Specific enzymatic cleavages at paired basic residues yield the different active peptides.
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
Secreted.
Note: Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.
ACTH and MSH are produced by the pituitary gland.
Belongs to the POMC family.
研究領域
· Organismal Systems > Endocrine system > Melanogenesis.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
参考文献
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