PTK7 Antibody - #DF2659
| 製品: | PTK7 Antibody |
| カタログ: | DF2659 |
| タンパク質の説明: | Rabbit polyclonal antibody to PTK7 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 86 kDa; 118kD(Calculated). |
| ユニプロット: | Q13308 |
| RRID: | AB_2839865 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2659, RRID:AB_2839865.
折りたたみ／展開
8430404F20Rik; CCK 4; CCK-4; Colon carcinoma kinase 4; Human colon carcinoma kinase 4 (CCK4) mRNA complete cds; Inactive tyrosine-protein kinase 7; mPTK7/CCK4; OTTHUMP00000217016; Protein tyrosine kinase PTK 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK 7; PTK7; PTK7 protein tyrosine kinase 7; PTK7 protein tyrosine kinase; PTK7_HUMAN; Serum response factor; Srf; Tyrosine-protein kinase-like 7;
免疫原
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
- Q13308 PTK7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13308 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S39 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| N116 | N-Glycosylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| N175 | N-Glycosylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| N268 | N-Glycosylation | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| N283 | N-Glycosylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| K636 | Ubiquitination | Uniprot | |
| N646 | N-Glycosylation | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| T785 | Phosphorylation | Uniprot | |
| S786 | Phosphorylation | Uniprot | |
| K788 | Ubiquitination | Uniprot | |
| S795 | Phosphorylation | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| K830 | Ubiquitination | Uniprot | |
| K835 | Ubiquitination | Uniprot | |
| Y872 | Phosphorylation | Uniprot | |
| Y877 | Phosphorylation | Uniprot | |
| K898 | Ubiquitination | Uniprot | |
| K905 | Ubiquitination | Uniprot | |
| K929 | Ubiquitination | Uniprot | |
| K945 | Ubiquitination | Uniprot | |
| S958 | Phosphorylation | Uniprot | |
| Y960 | Phosphorylation | Uniprot | |
| Y961 | Phosphorylation | Uniprot | |
| K1035 | Ubiquitination | Uniprot | |
| K1069 | Ubiquitination | Uniprot |
研究背景
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Membrane>Single-pass type I membrane protein. Cell junction.
Note: Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Interacts with CTNNB1.
The protein kinase domain is predicted to be catalytically inactive.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
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