TTBK2 Antibody - #DF2688
| 製品: | TTBK2 Antibody |
| カタログ: | DF2688 |
| タンパク質の説明: | Rabbit polyclonal antibody to TTBK2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 137 kDa; 137kD(Calculated). |
| ユニプロット: | Q6IQ55 |
| RRID: | AB_2839894 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2688, RRID:AB_2839894.
折りたたみ／展開
KIAA0847; mKIAA0847; SCA11; Spinocerebellar ataxia 11; Tau tubulin kinase 2; Tau-tubulin kinase 2; TTBK; TTBK 2; TTBK1; TTBK2; TTBK2_HUMAN; TTK;
免疫原
- Q6IQ55 TTBK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGEPPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEKSILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKNNEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFLHQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6IQ55 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K70 | Sumoylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| Y242 | Phosphorylation | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| T322 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| T431 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| K476 | Ubiquitination | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| T613 | Phosphorylation | Uniprot | |
| S614 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S751 | Phosphorylation | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S786 | Phosphorylation | Uniprot | |
| S794 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| T828 | Phosphorylation | Uniprot | |
| T830 | Phosphorylation | Uniprot | |
| K845 | Acetylation | Uniprot | |
| K877 | Acetylation | Uniprot | |
| S879 | Phosphorylation | Uniprot | |
| S960 | Phosphorylation | Uniprot | |
| S963 | Phosphorylation | Uniprot | |
| K985 | Ubiquitination | Uniprot | |
| S1039 | Phosphorylation | Uniprot | |
| S1042 | Phosphorylation | Uniprot | |
| S1103 | Phosphorylation | Uniprot | |
| T1139 | Phosphorylation | Uniprot | |
| S1143 | Phosphorylation | Uniprot | |
| S1152 | Phosphorylation | Uniprot | |
| S1154 | Phosphorylation | Uniprot | |
| S1157 | Phosphorylation | Uniprot | |
| S1240 | Phosphorylation | Uniprot | |
| S1243 | Phosphorylation | Uniprot |
PTMs - Q6IQ55 酵素として
研究背景
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Cell projection>Cilium. Cytoplasm>Cytoskeleton>Cilium basal body. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytosol. Nucleus.
Note: Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus.
Interacts with CEP164.
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.