製品: SS3R Antibody
カタログ: DF2778
タンパク質の説明: Rabbit polyclonal antibody to SS3R
アプリケーション: WB IHC
反応性: Human
予測: Rat, Pig, Bovine, Sheep
分子量: 46 kDa; 46kD(Calculated).
ユニプロット: P32745
RRID: AB_2839984

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Rat(%), Pig(82%), Bovine(100%), Sheep(100%)
クローナリティ:
Polyclonal
特異性:
SS3R Antibody detects endogenous levels of total SS3R.
RRID:
AB_2839984
引用形式: Affinity Biosciences Cat# DF2778, RRID:AB_2839984.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

OTTHUMP00000028737; Smstr 3; Smstr3; Somatostatin receptor subtype 3; Somatostatin receptor type 3; SS 3R; SS-3-R; SS3-R; SS3R; SSR 28; SSR-28; SSR28; SSR3_HUMAN; Sst 3; Sst3; SSTR 3; SSTR3;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P32745 SSR3_HUMAN:

Brain, pituitary and pancreas.

タンパク質の説明:
Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
タンパク質配列:
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
100
Sheep
100
Pig
82
Horse
67
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P32745 基板として

Site PTM Type Enzyme
R71 Methylation
Y142 Phosphorylation
Y303 Phosphorylation
S332 Phosphorylation
S337 Phosphorylation
T341 Phosphorylation
T348 Phosphorylation
S361 Phosphorylation

研究背景

機能:

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

PTMs:

Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).

細胞の位置付け:

Cell membrane>Multi-pass membrane protein.
Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Brain, pituitary and pancreas.

サブユニット構造:

Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).

タンパク質ファミリー:

Belongs to the G-protein coupled receptor 1 family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

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