EDNRB Antibody - #DF2788
| 製品: | EDNRB Antibody |
| カタログ: | DF2788 |
| タンパク質の説明: | Rabbit polyclonal antibody to EDNRB |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
| 分子量: | 50 kDa; 50kD(Calculated). |
| ユニプロット: | P24530 |
| RRID: | AB_2839994 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2788, RRID:AB_2839994.
折りたたみ／展開
ABCDS; Ednra; EDNRB; EDNRB_HUMAN; Endothelin B receptor; Endothelin B receptor precursor; Endothelin receptor Non selective type; Endothelin receptor non-selective type; Endothelin receptor type B; ET B; ET-B; ET-BR; ETB; ETBR; ETRB; Hirschsprung disease 2; HSCR; HSCR2; OTTHUMP00000018534; OTTHUMP00000178736; WS4A;
免疫原
Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
- P24530 EDNRB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P24530 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T52 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| Y200 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S419 | Phosphorylation | Uniprot | |
| Y430 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot |
研究背景
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405.
Cell membrane>Multi-pass membrane protein.
Note: internalized after activation by endothelins.
Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
· Organismal Systems > Endocrine system > Relaxin signaling pathway.
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