GPR161 Antibody - #DF2798
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| 製品: | GPR161 Antibody |
| カタログ: | DF2798 |
| タンパク質の説明: | Rabbit polyclonal antibody to GPR161 |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 65 kDa; 59kD(Calculated). |
| ユニプロット: | Q8N6U8 |
| RRID: | AB_2840004 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2798, RRID:AB_2840004.
折りたたみ／展開
G protein coupled receptor 161; G protein coupled receptor RE2; RE2;
免疫原
- Q8N6U8 GP161_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFSISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N6U8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y57 | Phosphorylation | Uniprot | |
| T226 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| T490 | Phosphorylation | Uniprot | |
| T493 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot |
研究背景
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Cell projection>Cilium membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
Note: Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
参考文献
Application: IHC Species: Rat Sample: lung
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