Phospho-FANCG (Ser383) Antibody - #AF0055
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0055, RRID:AB_2834098.
折りたたみ／展開
DNA repair protein XRCC9; FAG; FANCG; FANCG_HUMAN; Fanconi anaemia complementation group G; Fanconi anemia group G protein; Protein FACG; X ray repair, complementing defective, in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9;
免疫原
A synthesized peptide derived from human FANCG around the phosphorylation site of Ser383.
- O15287 FANCG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALEGLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQRSLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAALWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQDAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTAELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKHILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFLEAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYCPLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFNCEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNRDTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLSWIRPSDRDAFLEEFRTSLPKSCDL
PTMs - O15287 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| S383 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S387 | Phosphorylation | P06493 (CDK1) | Uniprot |
| K430 | Ubiquitination | Uniprot | |
| T487 | Phosphorylation | P06493 (CDK1) | Uniprot |
| K491 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| T557 | Phosphorylation | Uniprot | |
| K559 | Ubiquitination | Uniprot | |
| K618 | Ubiquitination | Uniprot |
研究背景
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
Nucleus. Cytoplasm.
Note: The major form is nuclear. The minor form is cytoplasmic.
Highly expressed in testis and thymus. Found in lymphoblasts.
Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. In complex with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. The complex with FANCC and FANCG may also include EIF2AK2 and HSP70. When phosphorylated at Ser-7, forms a complex with BRCA2, FANCD2 and XRCC3.
研究領域
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
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