FIR Antibody - #AF0527
| 製品: | FIR Antibody |
| カタログ: | AF0527 |
| タンパク質の説明: | Rabbit polyclonal antibody to FIR |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Horse, Sheep, Dog |
| 分子量: | 119kDa; 120kD(Calculated). |
| ユニプロット: | O94887 |
| RRID: | AB_2834192 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0527, RRID:AB_2834192.
折りたたみ／展開
FARP2; FARP2_HUMAN; FERM; FERM domain including RhoGEF; FERM, RhoGEF and pleckstrin domain protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2; FGD1 related Cdc42 GEF; FIR; FRG; KIAA0793; PH domain-containing family C member 3; Pleckstrin homology domain-containing family C member 3; PLEKHC3; RhoGEF and pleckstrin domain protein 2; RhoGEF and pleckstrin domain-containing protein 2;
免疫原
- O94887 FARP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O94887 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y8 | Phosphorylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| T34 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| R337 | Methylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| R342 | Methylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| Y365 | Phosphorylation | Uniprot | |
| T380 | Phosphorylation | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| T396 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| S401 | Phosphorylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| Y407 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| Y436 | Phosphorylation | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| T474 | Phosphorylation | Uniprot | |
| S476 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| Y537 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| T577 | Phosphorylation | Uniprot | |
| S581 | Phosphorylation | Uniprot | |
| T645 | Phosphorylation | Uniprot | |
| T868 | Phosphorylation | Uniprot | |
| S876 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot | |
| T907 | Phosphorylation | Uniprot | |
| T908 | Phosphorylation | Uniprot | |
| Y914 | Phosphorylation | Uniprot | |
| S1033 | Phosphorylation | Uniprot |
研究背景
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1 (By similarity).
Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
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