PSMD2 Antibody - #AF0707
| 製品: | PSMD2 Antibody |
| カタログ: | AF0707 |
| タンパク質の説明: | Rabbit polyclonal antibody to PSMD2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 100kDa; 100kD(Calculated). |
| ユニプロット: | Q13200 |
| RRID: | AB_2834249 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0707, RRID:AB_2834249.
折りたたみ／展開
26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; MGC14274; P97; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit, non-ATPase, 2; Proteasome 26S, subunit 2; Protein 55.11; Psmd2; PSMD2_HUMAN; Rpn1; S2; TNFR associated protein 2; TRAP2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2;
免疫原
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
- Q13200 PSMD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13200 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Ubiquitination | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| T24 | Phosphorylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| R79 | Methylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| R137 | Methylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| Y158 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| Y226 | Phosphorylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| K350 | Acetylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| R357 | Methylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| Y434 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| T499 | Phosphorylation | Uniprot | |
| S508 | Phosphorylation | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| Y554 | Phosphorylation | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| S711 | Phosphorylation | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| K773 | Ubiquitination | Uniprot | |
| K858 | Ubiquitination | Uniprot | |
| K860 | Ubiquitination | Uniprot | |
| K902 | Ubiquitination | Uniprot | |
| Y906 | Phosphorylation | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L (By similarity). Interacts with CRY1 in a KDM8-dependent manner (By similarity).
Belongs to the proteasome subunit S2 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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